Nucleic acid sequences encoding peptides with utrophin spectrin-like repeats
AssigneeThe Regents of the University of Michigan
InventorsJeffrey S. Chamberlain, Scott Q. Harper
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Abstract
The present invention relates to compositions and methods for expressing mini-dystrophin peptides. In particular, the present invention provides compositions comprising nucleic acid sequences that are shorter than wild-type dystrophin cDNA and that express mini-dystrophin peptides that function in a similar manner as wild-type dystrophin proteins. The present invention also provides compositions comprising mini-dystrophin peptides, and methods for expressing mini-dystrophin peptides in target cells.
Claims11
1-8. (canceled)
A composition comprising nucleic acid encoding a peptide, wherein said peptide comprises a spectrin-like repeat domain comprising 4 utrophin spectrin-like repeats, wherein said peptide contains no more than 4 utrophin spectrin-like repeats.
A composition comprising nucleic acid encoding a peptide, wherein said peptide comprises a spectrin-like repeat domain comprising 8 utrophin spectrin-like repeats, wherein said peptide contains no more than 8 utrophin spectrin-like repeats.
Dependencies are inferred from the claim text.