Oligonucleotide-Containing Pharmacological Compositions And Their Use

A composition suitable for administration in a mammal suffering from a pathological disorder or disease comprising at least two modified oligonucleotides, wherein a first and a second modified oligonucleotide each comprises about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleotide phosphate linkages, and wherein said first modified oligonucleotide is complementary to a region of a first gene associated with said pathological disorder or disease and said second modified oligonucleotide is complementary to a region of a second gene associated with said pathological disorder or disease, wherein said pathological disorder is selected from the group consisting of abnormal appetite, hypertension, hypercholesterolemia, hyperlipidemia, erectile dysfunction, eczema, depression, anxiety, stress, inflammatory bowel syndrome, ulcerative colitis, Crohn's disease, renal stones, gall stones, constipation, migraine headache, seizure, multiple sclerosis, polymyositis, fibromyalgia, Parkinson's disease, ALS, chronic pain, pre-menstrual syndrome, chronic allergies, sinusitis, colds, trauma, carpal tunnel syndrome, chronic fatigue syndrome, rosacea, arthritis, psoriasis, prostatitis, inflammation, heartburn, infection, and poison ivy.

A nutritional supplement comprising two or more modified oligonucleotides each comprising about seven to seventy-file nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphate linkages wherein each of said two or more modified oligonucleotides is complementary to a region of a gene associated with said pathological disorder or disease, and wherein said pathological disorders are selected from the group consisting of:

• stress, migraine headache, minor or temporary pain, prostatitis, premenstrual syndrome, menstrual cramping, bloating, nausea, irritability, nervous tension, anxiety, and lack of control of appetite.

A method of treating a patient with a pathological disorder comprising administering at least two modified oligonucleotides, wherein a first and a second modified oligonucleotide each comprises about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleotide phosphate linkages, and wherein said first modified oligonucleotide is complementary to a region of a first gene associated with said pathological disorder or disease and said second modified oligonucleotide is complementary to a region of a second gene associated with said pathological disorder or disease, wherein said pathological disorder is selected from the group consisting of abnormal appetite, hypertension, hypercholesterolemia, hyperlipidemia, erectile dysfunction, eczema, depression, anxiety, stress, inflammatory bowel syndrome, ulcerative colitis, Crohn's disease, renal stones, gall stones, constipation, migraine headache, seizure, multiple sclerosis, polymyositis, fibromyalgia, Parkinson's disease, ALS, chronic pain, pre-menstrual syndrome, sinusitis, colds, trauma, carpal tunnel syndrome, chronic fatigue syndrome, rosacea, arthritis, psoriasis, prostatitis, inflammation, heartburn, infection, and poison ivy.