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US 2008/0167255 A1Published application
4-biarylyl-1-phenylazetidin-2-ones
AssigneeMicrobia, Inc.
InventorsEduardo J. Martinez, John J. Talley, Stephen Antonelli, Timothy C. Barden, Regina Lundrigan-Soucy, Wayne C. Schairer, Jing-Jing Yang, Daniel P. Zimmer, Brian Cali, Mark G. Currie, Peter S. Yorgey
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Abstract
4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
Claims29
1-139. (canceled)
A compound of formula
- wherein
- R1i and R2i are chosen from H, Cl and F;
- and
- R5i is chosen from OH and SO3H.
1 more element
Sodium 4′-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3′-hydroxybiphenyl-4-sulfonate.
Dependencies are inferred from the claim text.