Method for Treating a Patient Undergoing Chemotherapy
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere S. DiZerega
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Abstract
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood following chemotherapy, comprising administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a patient in need of chemotherapy.
Claims19
1-34. (canceled)
An improved method for multiple cycle chemotherapy in a human patient, wherein the improvement comprises administering to the human chemotherapy patient an amount effective of a polypeptide consisting of at least 5 amino acids of SEQ ID NO:4 to permit treatment of the human chemotherapy patient with at least the same chemotherapy dosage on a second or further chemotherapy cycle as on the first chemotherapy cycle.
Dependencies are inferred from the claim text.