Protective factors against inflammation, burns and noxious stimuli
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorUri Wormser
Life of this patent
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Abstract
Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. Pharmaceutical compositions and methods of using these peptides are also disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the prevention and treatment of inflammatory conditions and exposure to noxious stimuli.
Claims23
A method for preventing, treating or managing symptoms in an individual having an inflammatory or autoimmune disease which comprises administering to an individual in need of such treatment a therapeutically effective amount of a peptide selected from the group consisting of SEQ ID NOs:1, 5-8, 10-14 and 16.
A method for preventing, treating or managing symptoms in an individual having an inflammatory or autoimmune disease which comprises administering to an individual in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a peptide selected from the group consisting of SEQ ID NOs:
- 1, 5-8, 10-14 and 16, and a pharmaceutically acceptable diluent or excipient.
A method for treating a degenerative-disease in an individual which comprises administering to an individual in need of such treatment a therapeutically effective amount of a peptide selected from the group consisting of SEQ ID NOs:1, 5-8, 10-14 and 16.
A method for treating a degenerative disease in an individual which comprises administering to an individual in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a peptide selected from the group consisting of SEQ ID NOs:1, 5-8, 10-14 and 16, and a pharmaceutically acceptable diluent or excipient.
A method of preventing or treating bone marrow damage in an individual which comprises administering to an individual in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a peptide selected from the group consisting of SEQ ID NOs:1, 5-8, 10-14 and 16, and a pharmaceutically acceptable diluent or excipient.
Dependencies are inferred from the claim text.