Methods and compositions for healing and repair of articular cartilage
AssigneeWyeth
InventorsRenwen Zhang, Diane Peluso, Elisabeth Morris
Life of this patent
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Abstract
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
Claims13
1-14. (canceled)
A method for treating osteoarthritis comprising administering to an area in need of regeneration of articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of at least one purified bone morphogenetic protein (BMP) in an amount effective for the regeneration of articular cartilage.
A method for treating osteoarthritis comprising administering to an area in need of regeneration of articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of:
- (i) at least one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, 7, and heterodimers and mixtures thereof in an amount effective for the regeneration of articular cartilage;
- and
- (ii) at least one pharmaceutical carrier selected from the group consisting of hyaluronic acid, surgical mesh or sutures, polyglyconate, temperature-sensitive polymers, demineralized bone, mineral, calcium phosphate, a ceramic, hydroxyapatite, and combinations thereof.
A method for treating osteoarthritis comprising administering to an area in need of regeneration of articular cartilage an osteochondral graft and a composition consisting essentially of at least one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, 7, and heterodimers and mixtures thereof, in an amount effective for the regeneration of articular cartilage, wherein said composition is applied directly to the osteochondral graft and administered directly to the site in need of tissue repair in conjunction with the graft.
A method for treating osteoarthritis comprising administering to an area in need of regeneration of articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of at least one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, 7, and heterodimers and mixtures thereof, in an amount effective for the regeneration of articular cartilage, wherein the area in need of regeneration of articular cartilage is selected from the group consisting of the hip and the knee.
A method for treating osteoarthritis comprising administering to an area in need of regeneration of articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of a heterodimeric protein in an amount effective for the regeneration of articular cartilage, wherein the heterodimeric protein comprises one purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 and one protein which induces the formation of tendon or ligament tissue selected from the group consisting of BMP-12, BMP-13, and MP52.
Dependencies are inferred from the claim text.