Active complex of alpha-lactalbumin (HAMLET) and cofactor
AssigneeNYA Hamlet Pharma AB
InventorCatharina Svanborg
Life of this patent
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Abstract
The use of a biologically active complex of α-lactalbumin, selected from HAMLET (human α-lactalbumin made lethal to tumour cells) or a biologically active modification thereof, or a biologically active fragment of either of these, in the preparation of a medicament for use in the treatment of papilloma, such as cutaneous papillomas.
Claims16
A method for treating papilloma which comprises administering to a patient in need thereof, a biologically active complex of alpha-lactalbumin and a cis C18 unsaturated fatty acid cofactor which stabilizes the complex in a biologically active form, wherein alpha-lactalbumin is selected from the group consisting of:
- (i) an alpha-lactalbumin identified by SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4,
- (ii) an alpha-lactalbumin comprising the region from amino acid 34-86 of human alpha-lactalbumin as identified by SEQ ID NO:1,
- (iii) an alpha-lactalbumin variant which has at least 95% identity to human alpha-lactalbumin as identified by SEQ ID NO:1, or has at least 95% identity to bovine alpha-lactalbumin as identified by SEQ ID NO:2, and wherein said variant has alpha-lactalbumin activity, and
- (iv) an alpha-lactalbumin variant identified by SEQ ID NO:5 or SEQ ID NO:6.
Dependencies are inferred from the claim text.