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US 2008/0167224 A1Published application
Variants of the nk1 fragment of hepatocyte growth factor/scatter factor (hgf/sf) and their use
AssigneeMedical Research Council
InventorsErmanno Gherardi, Daniel Lietha, Thomas Leon Blundell, Dimitry Yurievich Chirgadze
Life of this patent
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Abstract
Variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use are disclosed. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF (SEQ ID NO:2) and these substitutions provide variants which show scatter factor activity and induce DNA synthesis. In vivo, the variants provide protection from liver damage in a model of acute liver failure.
Claims15
1-18. (canceled)
A polypeptide which is a variant of SEQ ID NO:
- 1, said variant having the sequence of SEQ ID NO:
- 1 apart from a substitution of least one of positions 132, 134, 170 and 181.
Dependencies are inferred from the claim text.