Methods and Compositions for Using Tsh in the Inhibition of Tnf Activity
AssigneeMount Sinai School of Medicine
InventorsMone Zaidi, Etsuka Abe, Terry Davies
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Abstract
The present invention is direct to methods and compositions for inhibiting TNF activity. In particular it has been found that TSH may be used to inhibit the activity of TNF. Methods and compositions for exploiting this finding are described.
Claims13
A method of inhibiting tumor necrosis factor (TNF) activity, in a cell that expresses TNF or a TNF receptor, comprising contacting said cell with a composition comprising thyroid stimulating hormone (TSH).
A method of decreasing an inflammatory response in an animal comprising administering to said animal a composition comprising TSH in an amount effective to inhibit the activity and/or expression of TNF in said animal.
A method of treating a disease characterized by an elevated TNF activity and/or expression in an animal comprising administering to said animal a composition comprising TSH in an amount effective to decrease the TNF activity in said animal.
Dependencies are inferred from the claim text.