Method For Synthesizing Derivative, Compound Library and Method For Constructing the Same, and Method For Screening

A method for constructing a compound library containing a derivative of an organic compound synthesized by reacting the organic compound produced by a microorganism with a reaction reagent, comprising the steps of:

• recovering a compound which is contained in a culture broth containing the reaction reagent and having been used for culturing the microorganism but is not contained in a culture broth substantially not containing the reaction reagent;
• and
• making the compound a member of the compound library.

A compound library containing a derivative of an organic compound synthesized by reacting the organic compound produced by a microorganism with a reaction reagent,

• being constructed by recovering a compound which is contained in a culture broth containing the reaction reagent and having been used for culturing the microorganism but is not contained in a culture broth substantially not containing the reaction reagent and making the compound a member of the compound library.

A method for screening for a compound having a physiological activity using a compound library containing a derivative of an organic compound synthesized by reacting the organic compound produced by a microorganism with a reaction reagent, comprising steps of:

• constructing the compound library by recovering a compound which is contained in a culture broth containing the reaction reagent and having been used for culturing the microorganism but is not contained in a culture broth substantially not containing the reaction reagent;
• and
• making the compound a member of the compound library.

A method for screening for a therapeutic agent using a compound library containing a derivative of an organic compound synthesized by reacting the organic compound produced by a microorganism with a reaction reagent, comprising the steps of:

• administering each compound in the compound library to a disease model animal other than human, the compound library being constructed by recovering a compound which is contained in a culture broth containing the reaction reagent and having been used for culturing the microorganism but is not contained in a culture broth substantially not containing the reaction reagent and making the compound a member of the compound library;
• and
• evaluating whether or not the symptom of the disease is improved by the administration of the compound.