Surface for the immobilization of ligands
AssigneeGraffinity Pharmaceuticals AG
InventorsStefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
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Abstract
The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
Claims20
A process for the generation of a binding layer on the metal surface of a solid phase carrier, comprising the step of contacting a solution of a plurality of identical or different anchor molecules represented by the formula
- HS—R-M
- wherein the structural moiety R provides for the formation of a self-assembling monolayer on the surface and M represents a mercaptophilic head group, with the surface under acidic conditions.
A process for the solid phase synthesis of an anchor molecule having the formula
- HS—R-M
- wherein the structural moiety R provides for the formation of a self-assembling monolayer on the surface and M represents a mercaptophilic head group,
- wherein the anchor molecule is coupled to a solid synthesis phase via the thiol group and is cleaved off in an acidic medium to provide the free anchor molecule.
Dependencies are inferred from the claim text.