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AssigneeGenmab A/S
InventorsJan G.J. van de Winkel, Marcus A. van Dijk, Janine Schuurman, Arnout F. Gerritsen, Ole Baadsgaard, Jorgen Petersen
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Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
An isolated nucleic acid encoding a heavy chain variable region of an antibody, wherein the variable region comprises the amino acid sequence set forth in SEQ ID NO:2, or an amino acid sequence at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a light chain variable region of an antibody, wherein the variable region comprises the amino acid sequence set forth in SEQ ID NO:4, or an amino acid sequence at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a heavy chain variable region of an antibody, wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:1, or a nucleotide sequence at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a light chain variable region of an antibody, wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:3, or a nucleotide sequence at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a variable region of an antibody, wherein the antibody comprises a heavy and light chain variable region having the amino acid sequences set forth in SEQ ID NOs:2 and 4, respectively, or amino acid sequences at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a variable region of an antibody, wherein the antibody comprises a heavy and light chain variable region encoded by the nucleotide sequences set forth in SEQ ID NOs:1 and 3, respectively, or nucleotide sequences at least 80% identical thereto, and wherein the antibody binds to human IL-15.
An isolated nucleic acid encoding a variable region of an antibody that binds an epitope on human IL-15 recognized by an antibody comprising heavy chain and human light chain variable regions comprising the amino acid sequences set forth in SEQ ID NO:2 and SEQ ID NO:4, respectively.
An isolated nucleic acid encoding a heavy chain variable region of an antibody, wherein the variable region comprises CDR1, CDR2, and CDR3 sequences as shown in SEQ ID NOs:5, 6, and 7, respectively, and wherein the antibody binds human IL-15.
An isolated nucleic acid encoding a light chain variable region of an antibody, wherein the variable region comprises CDR1, CDR2, and CDR3 sequences as shown in SEQ ID NOs:8, 9, and 10, respectively, and wherein the antibody binds human IL-15.
An isolated nucleic acid encoding a variable region of an antibody, wherein the antibody binds human IL-15 and comprises
Dependencies are inferred from the claim text.