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US 2008/0166800 A1Published application
Method and medicament for inhibiting the expression of a given gene
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsRoland Kreutzer, Stefan Limmer
Life of this patent
Estimating the term…
Abstract
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA.
Claims26
1-3. (canceled)
An isolated double stranded RNA (dsRNA) consisting of two separate complementary oligoribonucleotide strands,
- wherein each of said strands consists of 15-25 nucleotides in length,
- said dsRNA consists of 15-25 base pairs,
- one strand of said dsRNA is complementary to less than the full length of an RNA transcript of said mammalian target gene,
- and wherein said dsRNA specifically inhibits the expression of said mammalian target gene.
1 more element
An isolated double stranded RNA (dsRNA) consisting of two separate complementary oligoribonucleotide strands,
- wherein the dsRNA is 21 nucleotides in length,
- wherein the dsRNA does not comprise a full length RNA transcript of a mammalian target gene,
- wherein one strand of the dsRNA is complementary to less than the full length of an RNA transcript of said mammalian target gene,
- and wherein the dsRNA specifically inhibits the expression of said mammalian target gene.
1 more element
Dependencies are inferred from the claim text.