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US 2008/0166794 A1Published application
Devices and Methods for Pharmacokinetic-Based Cell Culture System
OwnerMichael Shuler, Gregory T. Baxter +3inventors
InventorsMichael Shuler, Gregory T. Baxter, Aaron Sin, Robert Andrew Harrison, Scott Meyers
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Abstract
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
Claims21
A pharmacokinetic-based microscale culture device, comprising:
- a first microscale chamber containing a first type of cell under conditions where the first type of cell provides at least one pharmacokinetic parameter value comparable to a value obtained for the same type of cell in vivo, wherein the first chamber comprises a first inlet and a first outlet for flow of culture medium;
- a second microscale chamber containing a second type of cell under conditions where the second type of cell provides at least one pharmacokinetic parameter value comparable to a value obtained for the same type of cell in vivo, wherein the second chamber comprises a second inlet and a second outlet for flow of culture medium;
- and a microfluidic channel interconnecting the first and second chambers.
21-178. (canceled)
Dependencies are inferred from the claim text.