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US 2008/0166783 A1Published application
In vivo incorporation of unnatural amino acids
AssigneeThe Scripps Research Institute and The Regents of the University of California
InventorsPeter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
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Abstract
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
Claims11
1-140. (canceled)
A translation system, comprising:
- a nucleic acid comprising a selector codon, wherein the nucleic acid is homologous to an insulin-like growth factor (IGF);
- an unnatural amino acid;
- an orthogonal tRNA (OtRNA) that recognizes the selector codon;
- and,
- an orthogonal aminoacyl tRNA synthetase (ORS) that preferentially aminoacylates the OtRNA with the unnatural amino acid, wherein the translation system translates the nucleic acid into a polypeptide, incorporating the unnatural amino acid into the polypeptide in response to the selector codon.
2 more elements
Dependencies are inferred from the claim text.