Fungal cell wall synthesis gene

An isolated DNA that encodes a protein having an activity to decrease the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus due to a defect in the function of the DNA, wherein the DNA is selected from the group consisting of:

• (a) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:40,
• (b) a DNA comprising the nucleotide sequence of SEQ ID NOs:39 or 41,
• (c) a DNA that hybridizes under stringent conditions to a DNA comprising the nucleotide sequence of SEQ ID NOs:
• 39 or 41, wherein said stringent conditions are (i) 4×SSC at 65° C., then washing in 0.1×SSC for 1 hour at 65° C.,
• (d) a DNA that hybridizes under stringent conditions to a DNA comprising the nucleotide sequence of SEQ ID NOs:
• 39 or 41, wherein said stringent conditions are 4×SSC at 42° C. in 50% formamide,
• (e) a DNA that hybridizes under stringent conditions to a DNA comprising the nucleotide sequence of SEQ ID NOs:
• 39 or 41, wherein said stringent conditions are PerfectHyb™ (TOYOBO) solution for 2.5 hours at 65° C., then washing in (i) 2×SSC, 0.05% SDS solution at 25° C. for 5 minutes, (ii) 2×SSC, 0.05% SDS solution at 25° C. for 15 minutes, and (iii) 0.1×SSC, 0.1% SDS solution at 50° C. for 20 minutes, and,
• (f) a DNA encoding a protein comprising the amino acid sequence of SEQ ID NO:40, wherein one or more amino acids have been added, deleted, substituted, and/or inserted.