Method for Diagnosing Membranous Glomerulonephritis Disease and a Kit Thereof
AssigneeIndustrial Technology Research Institute
InventorsTzu-Ling Tseng, Pei-Hsiu Liao, Ping-Fu Cheng, Chi-Hung Cheng
Life of this patent
Estimating the term…
Abstract
Some specific autoantigens of MGN are discovered by using the integrated platform. Moreover, according to the specificity between antibodies and antigens, a method for diagnosing MGN are constructed. This diagnostic method is cooperated with ELISA, RIA, immunofluorescence, or other immunochromatography techniques. Finally, a diagnostic kit is provided to implement the method above.
Claims10
A method of diagnosing membranous glomerulonephritis disease in a subject comprising:
- obtaining a biological sample from the subject;
- and
- detecting at least one autoantibody in the biological sample, wherein the autoantibody specifically binds at least one protein selected from a group consisting of laminin alpha-1 chain precursor, glycogen phosphorylase, catalase, α-amylase, and glyceraldehyde-3-phosphate dehydrogenase,
- when the autoantibody presents in the biological sample indicates that the subject has membranous glomerulonephritis disease.
A kit for identifying a subject having membranous glomerulonephritis disease comprising reagents for determining presence of at least one autoantibody that specifically binds one or more proteins selected from a group consisting of laminin alpha-1 chain precursor, glycogen phosphorylase, catalase, α-amylase, and glyceraldehyde-3-phosphate dehydrogenase in a biological sample.
Dependencies are inferred from the claim text.