Metabolic Method To Identify Compounds
AssigneeGivaudan SA
InventorBoris Schilling
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Abstract
The invention is concerned with the identification of compounds as flavours or fragrances, their precursors, or as modulators of the perception of fragrances or flavours. The method comprises a reaction of a compound with a metabolic enzyme expressed in the nose, mouth or respiratory tract, followed by a method of identification of the compound or its metabolites as a fragrance or flavour, their precursor, or a modulator of their perception or of the perception of their respective leads.
Claims12
Method of identifying a compound or its metabolite as a flavour or fragrance, or a precursor of a flavour or fragrance, or a modulator of the perception of a fragrance or flavour, or a lead for such compounds comprising
- a) reacting a compound with at least one metabolic enzyme selected from the group consisting of dehydrogenase, Cytochrome P450 enzyme, epoxide hydrolase, esterase, flavin-containing monooxygenase, glutathione peroxidase, glutathione synthase, glutathione S-transferase, oxidase, reductase, rhodanese, sulfatase, sulfotransferase, UDP-glucuronosyltransferase, carboxyl esterase, or mixtures thereof;
- and
- b) identifying the compound or at least one of its metabolites as a fragrance or flavour, or a precursor of a flavour or fragrance, or a modulator of the perception of a fragrance or flavour or their respective leads using chemoreceptors.
Dependencies are inferred from the claim text.