Genes and methods of using the same for diagnosis and for targeting the therapy of cardiovascular disease
OwnerDavid Xing-Fei Denginventor
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Abstract
The invention is a method of classifying, diagnosing, prognosticating, and predicting cardiovascular disease conditions or other biological states using genes identified using microarray technology.
Claims38
A method for diagnosing cardiovascular disease or susceptibility to cardiovascular disease comprising:
- detecting a CXCL12 polypeptide in a biological sample, wherein an increase in CXCL12 polypeptide as compared to control sample is indicative of cardiovascular disease.
A method for screening for an antagonist of CXCL12 comprising:
- a) contacting a CXCL12 polypeptide with an agent;
- and
- b) determining whether the agent inhibits binding of CXCL12 to its receptor CXCR4 or inhibits an activity of the CXCL12.
A method for screening for an antagonist of CXCL12 comprising contacting polynucleotide encoding a CXCL12 polypeptide, with a candidate agent, and determining whether the candidate agent inhibits expression of the polypeptide.
A method for diagnosing cardiovascular disease or susceptibility to cardiovascular disease comprising:
- detecting expression of a polynucleotide encoding a CXCL12 polypeptide in a biological sample, wherein an increase in expression of a CXCL12 polypeptide as compared to control sample is indicative of cardiovascular disease.
Dependencies are inferred from the claim text.