Loading patent…
AssigneeThe Walter and Eliza Hall Institute of Medical Research
InventorsDouglas J. Hilton, Warren S. Alexander, Elizabeth M. Viney, Tracy A. Willson, Rachael T. Richardson, Robyn Starr, Sandra E. Nicholson, Donald Metcalf, Nicos A. Nicola
Estimating the term…
The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
1-16. (canceled)
A method of modulating signal transduction in a cell containing a SOCS gene, said method comprising identifying a modulator of SOCS gene expression or SOCS protein activity in a cell and contacting said cell with said identified modulator wherein the modulator binds to SOCS gene or SOCS protein for a time sufficient to modulate signal transduction.
(canceled)
26-30. (canceled)
Dependencies are inferred from the claim text.