Methods and Compositions for Determining Predisposition to Inflammation-Mediated Cardiovascular Disease
AssigneeChildren's Hospital & Research Center at Oakland
InventorsDavid M. Iovannisci, Edward J. Lammer
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Abstract
The present invention provides methods and compositions for detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject by detecting a level of leukotriene C4 synthase (LTC4S) gene product in a sample from a human subject indicative of a predisposition to an inflammation-mediated cardiovascular disease or detecting the presence or absence of an allele of LTC4S indicative of a predisposition to an inflammation-mediated cardiovascular disease. In addition, the present invention also provides kits for practicing the methods.
Claims25
A method of detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject, said method comprising:
- detecting a level of leukotriene C4 synthase (LTC4S ) gene product in a sample from a human subject,
- wherein an increased level of LTC4S gene product as compared to a reference level known to be associated with a non-risk of development of an inflammation-mediated cardiovascular disease indicates that the human subject has a predisposition to an inflammation-mediated cardiovascular disease.
A method of detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject, said method comprising:
- detecting the presence or absence of an allele of a leukotriene C4 synthase (LTC4S) indicative of a predisposition to an inflammation-mediated cardiovascular disease,
- wherein the presence of the allele indicates the human subject has a predisposition to an inflammation-mediated cardiovascular disease.
A device for use in detecting a predisposition to cardiovascular disease in a human subject, said device comprising:
- a leukotriene C4 synthase (LTC4S ) gene product affinity reagent immobilized on a surface of a solid support, and
- a reference known to be associated with a non-risk of development of an inflammation-mediated cardiovascular disease.
A kit for use in detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject, said kit comprising:
- reagents for assaying a sample for a leukotriene C4 synthase (LTC4S) gene product, and
- a reference known to be associated with a non-risk of development of an inflammation-mediated cardiovascular disease.
Dependencies are inferred from the claim text.