Antibodies for cancer therapy and diagnosis
OwnerPaul J. Carter, John B. Ridgwayinventors
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Abstract
The present application describes a method for making antibodies which can be used for cancer diagnosis or therapy. The application also discloses a method for identifying an antigen which is differentially expressed on the surface of two or more distinct cell populations. The application additionally describes human antibodies directed against decay accelerating factor (DAF), as well as therapeutic compositions comprising such antibodies. Moreover, the application discloses a method of treating lung cancer with antibodies directed against DAF.
Claims12
A method for making an antibody against an antigen which is shared by a cancer cell and a non-cancer cell comprising the following steps:
- (a) counter-selecting antibody phage from a naïve antibody phage library using a live non-cancer cell;
- (b) subsequently binding the antibody phage to a live cancer cell;
- (c) selecting an antibody phage or antibody which binds selectively to the live cancer cell;
- and
- (d) identifying an antigen to which the antibody phage or antibody binds.
Dependencies are inferred from the claim text.