Solution for the storage and perfusion of organs awaiting transplantation
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsArduini Arduino, Aureli Tommaso
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Abstract
A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b) 50-250 mM glucose; (c) 0.2-20 mM of an alkanoyl L-carnitine or a physiologically acceptable salt thereof; (d) 1 -100 mM of L-carnitine or a physiologically acceptable salt thereof; (e) water is described. The storage solution can also include other components such as anti-oxidants and/or chelating agents.
Claims10
-13. (canceled)
A solution comprising:
- a) K2PO4•3H2OK2HPO4•3H2O
- 10-60
- mM
- KH2PO4
- 3-50
- mM
- KCl
- 3-50
- mM
- NaHCO3
- 2-50
- mM
- b) glucose
- 50-250
- mM
- c) alkanoyl L-carnitine or
- 0.2-20
- mM and/or
- a physiologically acceptable
- salt thereof
- d) L-carnitine or
- 1-100
- mM
- a physiologically acceptable
- salt thereof
- e)water
- wherein the amount of L-carnitine is greater than the amount of alkanoyl L-carnitine, to maintain a perfused organ awaiting transplantation wherein the organ is selected from the group consisting of heart, liver, pancreas, lung and kidney.
A solution comprising:
- a) K2PO4•3H2OK2HPO4•3H2O
- 10-60 mM
- b) KH2PO4
- 3-50 mM
- c) KCl
- 3-50 mM
- d) NaHCO3
- 2-50 mM
- e) glucose
- 50-250 mM
- f) Isovaleryl L-carnitine Fumarate
- 0.2-20 mM
- g) L-carnitine
- 1-100 mM
- to maintain a perfused organ awaiting transplantation wherein the organ is selected from the group consisting of heart, liver, pancreas, lung and kidney.
Dependencies are inferred from the claim text.