Drugs And Gene Carrier Particles That Rapidly Move Through Mucous Barriers
AssigneeThe Johns Hopkins University
InventorsJustin Hanes, Michelle Rose Dawson, Denis Wirtz, Jie Fu, Eric Mark Krauland
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Abstract
The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
Claims25
A polymeric particle comprising a pharmaceutically acceptable polymer core, a bioactive agent, and a surface-altering agent disposed on the surface of the core that renders the surface of the polymeric particle mucus resistant and/or enhances the average rate at which the particles or a fraction of the particles moves in mucus.
A polymeric particle comprising a pharmaceutically acceptable polymer core and a bioactive agent disposed on the surface of the particle, wherein the bioactive agent renders the surface of the polymeric particle mucus resistant.
Dependencies are inferred from the claim text.