Back to results
US 2008/0166411 A1Published application
Injectable Depot Formulations And Methods For Providing Sustained Release Of Poorly Soluble Drugs Comprising Nanoparticles
AssigneePfizer Inc.
InventorsJaymin C. Shah, Parah Suresh Shah, Dawn Renee Wagner, Peter Wisniecki
Life of this patent
Estimating the term…
Abstract
Pharmaceutical formulations comprising: a compound of low water solubility, having a maximum average particle size; a carrier; and at least two surface stabilizers are disclosed. The present invention also comprises methods of treating various conditions with such a formulation and processes for making such a formulation.
Claims15
An injectable depot pharmaceutical formulation comprising:
- a) a pharmaceutically effective amount of a compound, the compound in the form of nanoparticles having an average particle size of less than about 2000 nm;
- b) a pharmaceutically acceptable carrier;
- and
- c) at least two surface stabilizers;
- wherein the compound has low water solubility;
- and wherein at least one of the surface stabilizers is adsorbed on the surface of the nanoparticles, and wherein the combined amount of the surface stabilizers is effective to maintain the average particle size of the nanoparticles.
3 more elements
An injectable depot pharmaceutical formulation comprising:
- a) a pharmaceutically effective amount of a compound of low water solubility, the compound in the form of nanoparticles having an average particle size of less than about 1200 nm;
- b) water;
- c) a first surface stabilizer adsorbed on the surface of the nanoparticles;
- and
- d) a second surface stabilizer;
- wherein the amount by weight of the compound is from about 20% by weight to about 60% by weight of the total volume of the formulation;
- wherein the amount by weight of a first surface stabilizer is from about 0.5% to about 2.0% by weight of the total volume of the formulation;
- wherein the amount by weight of a second surface stabilizer is from about 0.1% to about 2.0% by weight of the total volume of the formulation;
- and wherein amount of the first surface stabilizer and the amount of the second surface stabilizer are together effective to maintain the average particle size of the nanoparticles.
6 more elements
An injectable depot pharmaceutical formulation comprising:
- a) a pharmaceutically effective amount of a compound, the compound in the form of nanoparticles having an average particle size of less than about 2000 nm;
- b) a pharmaceutically acceptable carrier;
- and
- c) at least two surface stabilizers;
- wherein the compound has a logP of at least about 3 or greater;
- and wherein at least one of the surface stabilizers is adsorbed on the surface of the nanoparticles, and wherein the combined amount of the surface stabilizers is effective to maintain the average particle size of the nanoparticles.
3 more elements
An injectable depot pharmaceutical formulation comprising:
- a) a pharmaceutically effective amount of a compound, the compound in the form of nanoparticles having an average particle size of less than about 2000 nm;
- b) a pharmaceutically acceptable carrier;
- and
- c) at least two surface stabilizers;
- wherein the compound has a high melting point;
- and wherein at least one of the surface stabilizers is adsorbed on the surface of the nanoparticles, and wherein the combined amount of the surface stabilizers is effective to maintain the average particle size of the nanoparticles.
3 more elements
Dependencies are inferred from the claim text.