Solid oral formulations for combination therapy
OwnerShalaby W. Shalaby, Kenneth David Gray +1inventors
InventorsShalaby W. Shalaby, Kenneth David Gray, Joel T. Corbett
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Abstract
Multifunctional, single, bilayer, and trilayer coated tablets for combination therapy are formed wherein the bioactive agents responsible for the therapeutic multifunctionality are present as a combination of a gastric acid-reducing agent, such as omeprazole and ranitidine, and at least one analgesic/anti-inflammatory agent, such as acetaminophen, naproxen sodium, ibuprofen, tolmetin, and aspirin.
Claims14
A combination therapy coated tablet, comprising:
- (a) a therapeutically effective dose of a non-steroidal anti-inflammatory drug (NSAID);
- (b) a therapeutically effective dose of an agent for reducing gastric acid secretion;
- (c) a thermoplastic hydrophilic polymer;
- (d) a microparticular excipient;
- and
- (e) a cellulosic enteric coating.
A combination therapy coated tablet, comprising:
- (a) a therapeutically effective dose of an analgesic drug;
- (b) a therapeutically effective dose of an agent for reducing gastric acid secretion;
- (c) a thermoplastic hydrophilic polymer;
- (d) a microparticular excipient;
- and
- (e) a cellulosic enteric coating.
A combination therapy coated bilayer tablet comprising:
- (a) a first layer comprising a therapeutically effective dose of acetaminophen dispersed in a water-soluble thermoplastic polymer;
- the first layer providing for the delayed release of the acetaminophen;
- (b) a second layer comprising a therapeutically effective dose of a non-steroidal anti-inflammatory drug and a therapeutically effective dose of an agent for reducing gastric acid secretion, the second layer providing for the fast release of the non-steroidal anti-inflammatory drug and the agent for reducing gastric acid secretion;
- and
- (c) a polymeric enteric coating.
A combination therapy coated bilayer tablet comprising:
- a first layer comprising a therapeutically effective dose of an analgesic drug and a second layer comprising a therapeutically effective dose of an agent for reducing gastric acid secretion wherein each layer contains microparticular polymeric excipients and hydrophilic polymeric excipients.
A combination therapy coated trilayer tablet comprising:
- a first layer comprising a therapeutically effective dose of an analgesic drug, microparticular polymeric excipients, and hydrophilic polymeric excipients, a second layer comprising a therapeutically effective dose of an agent for reducing gastric acid secretion, microparticular polymeric excipients, and hydrophilic polymeric excipients, and a third, drug-free layer of a solid, water-soluble polymer adjoining the first and second drug-containing layers.
A combination therapy coated trilayer tablet comprising:
- a first layer comprising a therapeutically effective dose of an analgesic drug mixed with microparticular and hydrophilic polymeric excipients, a second layer comprising a mixture of microparticular and hydrophilic polymeric excipients, an inorganic base and a therapeutically effective dose of an agent for reducing gastric acid secretion and a third drug-free layer of a solid water-soluble polymer adjoining the first and second drug-containing layers.
Dependencies are inferred from the claim text.