Positive Modulator of Bone Morphogenic Protein-2

A compound of formula:

• wherein:
• X is a peptide chain that (i) has a minimum of three amino acid residues, (ii) has a maximum of about fifty amino acid residues, and (iii) binds specifically to a Bone Morphogenic Protein-2 receptor;
• R1 is independently hydrogen, such that the terminal group is NH2, an acyl group with a linear or branched C1 to C17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain including an N-terminus NH2, NH3+, or NH group or a corresponding acylated derivative, or is amino acid, a dipeptide or a tripeptide with an N-terminus NH2, NH3+, or NH group;
• R2 is independently a trifunctional alpha amino acid residue, wherein X is covalently bonded through a side chain of R2;
• R3 is independently a linker comprising a chain from 0 to about 15 backbone atoms covalently bonded to R2;
• R4 is OH such that the terminal group is a carboxyl, NH2, an acyl group with a linear or branched C1 to C17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain including an N-terminus NH2, NH3+, or NH group or a corresponding acylated derivative, or NH—R1;
• Y is a linker comprising a chain from 0 to about 50 backbone atoms covalently bonded to R2 and Z;
• and
• Z is a non-signaling peptide chain that includes a heparin binding domain comprising an amino acid sequence that comprises (i) a minimum of one heparin binding motif, (ii) a maximum of about ten heparin binding motifs, and (iii) a maximum of about thirty amino acids.