Death receptor sensitizing compounds and methods of use therefor
AssigneeThe Burnham Institute
InventorsAaron D. Schimmer, John C. Reed
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Abstract
Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
Claims40
A method to identify one or more agents that enhance TNF-family death receptor ligand-mediated killing of tumor cells, comprising:
- a) contacting an amount of one or more agents, tumor cells that express TNF-family death receptors on the cell surface and are resistant to TNF-family death receptor ligand-mediated apoptosis, and an agonistic TNF-family death receptor ligand;
- and
- b) identifying whether the one or more agents enhance TNF-family death receptor ligand-mediated killing of the tumor cells.
A method to enhance TNF-family death receptor ligand-mediated killing of tumor cells in a mammal, comprising administrating to a mammal in need of such therapy an effective amount of a compound of formula (I)-(IX).
A method to treat TNF-family death receptor ligand-resistant cancer in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I)-(IX).
A method to treat cells resistant to TNF-family death receptor ligand-mediated killing comprising contacting the cells with an effective amount of a compound of formula (I)-(IX).
A method to enhance the efficacy of a tumor vaccine, comprising administering to a mammal having cancer an effective amount of a tumor vaccine and an effective amount of a compound of formula (I)-(IX).
A method to inhibit metastases comprising administering to a mammal having cancer an effective amount of a compound of formula (I)-(IX) or FLIP siRNA.
A method to sensitize cells to anoikis, comprising administering to a mammal having cancer an effective amount of a compound of formula (I)-(IX) or FLIP siRNA.
Dependencies are inferred from the claim text.