Human Hookworm Vaccine
OwnerPeter Hotez, Alexander Loukas +5inventors
InventorsPeter Hotez, Alexander Loukas, Bin Zhan, Gaddam Goud, Jeffrey Bethony, Maria Elena Bottazzi, Aaron Miles
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Abstract
A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
Claims17
A vaccine composition, comprising,
- at least one larval-stage hookworm antigen;
- at least one adult-stage hookworm antigen;
- an aluminum-based adjuvant;
- and
- a second adjuvant.
A method for vaccinating a patient in need thereof against hookworm infections, comprising the step of
- administering to said patient a vaccine composition comprising,
- at least one larval-stage hookworm antigen;
- at least one adult-stage hookworm antigen;
- an aluminum-based adjuvant;
- and
- a second adjuvant.
A hookworm vaccine comprising
- a hookworm larval stage antigen;
- an hookworm adult stage antigen;
- and
- one or more adjuvants.
A method for vaccinating a patient in need thereof against hookworm infections, comprising the step of
- administering to said patient a vaccine composition comprising,
- a hookworm larval stage antigen;
- an hookworm adult stage antigen;
- and
- one or more adjuvants.
Dependencies are inferred from the claim text.