METHODS AND COMPOSITIONS FOR DELIVERY AND EXPRESSION OF INTERFERON-alpha NUCLEIC ACIDS
AssigneeCanji, Inc.
InventorsTattanahalli L. Nagabhushan, Deba P. Saha
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Abstract
The present invention is directed to compositions and methods for the delivery of interferon polypeptides. The invention provides recombinant viral and non-viral vectors for the selective expression of interferon polypeptides in particular cell or tissue types. The invention further provides pharmaceutically acceptable formulations of such vectors for administration to mammalian subjects. The invention further provides methods of treatment of diseases in mammalian organisms through the delivery of recombinant vectors selectively expressing interferon polypeptides.
Claims11
A method for increasing a subject's resistance to viral infection, comprising administering to a selected tissue of said subject a recombinant adenoviral vector comprising a nucleic acid segment encoding an interferon α2b or an interferon α2α1 polypeptide, wherein said nucleic acid segment encoding the interferon-α polypeptide lacks a secretion leader sequence and wherein said nucleic acid segment is operatively linked to a promoter specific for the cells of said selected tissue, wherein the interferon alpha polypeptide is expressed in said cells.
Dependencies are inferred from the claim text.