Immunogenic Compositions Comprising Multiple Gonococcal Antigens
AssigneeChiron Corporation
InventorsLaura Serino, Rosanna Leuzzi, Maria Rita Fontana, Elisabetta Monaci, Mariagrazia Pizza
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Abstract
N. gonorrhoeae is a bacterial pathogen which causes diseases including gonorrhoea, urethritis, cervicitis and pelvic inflammatory disease. In addition, like other inflammatory SYDs, infection is believed to enhance HIV transmission. Within the many proteins of the gonococcal *enome, six have been found to be particularly suitable for immunisation purposes, particularly', when used in combinations. The invention therefore provides a composition comprising two or more of the following antigens: (1) OmpA; (2) OmpH; (3) PPIase; (4) ngs41; (5) ngsl 17; and (6)', App.
Claims14
A composition comprising two or more of the following gonococcal antigens:
- (1) OmpA;
- (2) OmpH;
- (3) PPIase;
- (4) ngs41;
- (5) ngs117;
- and (6) App.
A lipidated gonococcal OmpA protein.
A lipidated gonococcal PPIase protein.
A dimeric gonococcal OmpH protein.
A dimeric gonococcal PPIase protein.
A gonococcus strain, wherein one or more of the following gonococcal antigens is knocked out:
- (1) OmpA;
- (2) OmpH;
- (3) PPIase;
- (4) ngs41;
- (5) ngs117;
- and (6) App.
Dependencies are inferred from the claim text.