Custom Vectors for Treating and Preventing Pancreatic Cancer
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
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Abstract
The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains a foreign nucleic acid encoding at least one pancreatic tumor associated antigen (PTAA).
Claims44
A method for inducing an immunological response against a malignant pancreatic cell in an individual, said method comprising the steps of:
- selecting an individual having malignant pancreatic cells or at risk for developing such a pancreatic tumor, administering to the individual a first vector containing a first gene, or antigenic portion thereof, that encodes a pancreatic tumor-associated antigen (PTAA), and at regular intervals thereafter administering at least a second vector containing a gene encoding PTAA or antigenic portion thereof, wherein if CEA or MUC-1 or an antigenic portion thereof or a modified version thereof is the PTAA, there must be a second PTAA present.
The method according to claim 7, wherein said poxvirus vector is selected from the group consisting of an orthopox virus vector;
- avipox virus vector;
- a suipox virus vector;
- a capripox virus vector;
- a leporipox virus vector;
- and an iridovirus vector.
A kit for enhancing a protective immune reaction against a pancreatic tumor comprising at least one pox vector encoding at least two PTAAs or antigenic portion thereof.
An isolated nucleic acid molecule encoding a Muc-1 fragment sufficient to generate an immune reaction to Muc-1.
An isolated nucleic acid molecule encoding one or more of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4, or a fragment or variant thereof.
A method for inducing an immunological response against a malignant pancreatic cell in an individual, comprising administering a therapeutically effective amount of a nucleic acid molecule encoding a Muc-1 fragment sufficient to generate an immune reaction to Muc-1.
A method for inducing an immunological response against a malignant pancreatic cell in an individual, comprising administering a therapeutically effective amount of one or more of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4, or a fragment or variant thereof.
A kit for enhancing a protective immune reaction against a pancreatic tumor comprising one or more of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4, or a fragment or variant thereof and instructions for use.
A kit for enhancing a protective immune reaction against a pancreatic tumor comprising one or more of an isolated nucleic acid molecule encoding a Muc-1 fragment sufficient to generate an immune reaction to Muc-1 and instructions for use.
Dependencies are inferred from the claim text.