Diagnostics and Therapeutics for Diseases Associated with Dipeptidyl-Peptidase 6 (Dpp6)

A method of screening for therapeutic agents useful in the treatment of a disease selected from the group consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammal, comprising the steps of

• i) determining activity of a DPP6 polypeptide at a certain concentration of a test compound or in the absence of said test compound, and
• ii) determining the activity of said polypeptide at a different concentration of said test compound.

A method of screening for therapeutic agents useful in the treatment of a disease consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammals comprising the steps of

• i) determining the activity of a DPP6 polypeptide at a certain concentration of a test compound, and
• ii) determining the activity of a DPP6 polypeptide at the presence of a compound known to be a regulator of a DPP6 polypeptide.

A method of screening for therapeutic agents useful in the treatment of a disease selected from the group consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammals comprising the steps of

• i) contacting a test compound with a DPP6 polynucleotide, and
• ii) detecting binding of said test compound to said DPP6 polynucleotide.

A method of diagnosing a disease selected from the group consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammal comprising the steps of

• i) determining the amount of a DPP6 polynucleotide in a sample taken from said mammal, and
• ii) determining the amount of DPP6 polynucleotide in healthy and/or diseased mammals.

19-20. (canceled)

A pharmaceutical composition for the treatment of a disease selected from the group consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammal, comprising a DPP6 polynucleotide.

A pharmaceutical composition for the treatment of a disease selected from the group consisting of cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, neurological diseases, urological diseases, reproduction disorders and respiratory diseases in a mammal, comprising a DPP6 polypeptide.

24-26. (canceled)