Dipterinyl calcium pentahydrate (DCP) and therapeutic methods based thereon
AssigneeSanRx Pharmaceuticals, Inc.
InventorsPhillip Moheno, Wolfgang Pfleiderer
Life of this patent
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Abstract
Provided herein is dipterinyl calcium pentahydrate (DCP) and therapeutic methods based thereon. Also provided herein is the compound dipterinyl calcium pentahydrate (DCP) or an analog or polymorph thereof.
Claims21
The compound dipterinyl calcium pentahydrate (DCP) or an analog or polymorph thereof.
A method of synthesizing dipterinyl calcium pentahydrate (DCP) comprising:
- dissolving pterin in an aqueous solution of NaOH,
- adding CaCl2.2H2O to the solution with stirring at a pH of about 11,
- continuing stirring for about 1 day, and
- collecting the precipitate as DCP.
A compound of formula (I):
- M(pterin)x(H2O)y
- wherein:
- M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
- X is an integr from 1 to 8;
- and
- y is an integer of from 1 to 8.
A method of treating disease in a subject comprising the administration of a therapeutically effective amount of a compound of formula (I):
- M(pterin)x(H2O)y
- wherein:
- M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
- X is an integr from 1 to 8;
- and
- y is an integer of from 1 to 8.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula (I):
- M(pterin)x(H2O)y
- wherein:
- M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
- X is an integr from 1 to 8;
- and
- y is an integer of from 1 to 8.
Dependencies are inferred from the claim text.