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AssigneeBiogen Idec MA Inc.
InventorsMichele Sanicola-Nadel, Kevin P. Williams, Susan Gail Schiffer, Paul Rayhorn
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The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.
A method of inhibiting proliferation of tumor cells in a subject comprising the step of administering to the subject an effective amount of a composition comprising a monoclonal antibody that binds to Cripto and a pharmaceutically acceptable carrier.
A method of treating a subject having a tumor that over-expresses Cripto comprising administering to the subject a composition comprising a monoclonal antibody that binds to Cripto and a pharmaceutically acceptable carrier in an effective amount.
Dependencies are inferred from the claim text.