Method for activating natural killer cells by tumor cell preparation in vitro
AssigneeUCL Biomodica PLC
InventorMark Lowdell
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Abstract
The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumour cell preparation (ATCP). The invention also provides an activated NK cell produced by such a method and its use in the treatment of cancer.
Claims16
A method for activating a Natural Killer (NK) cell, which comprises the step of contacting the NK cell in vitro with an activating tumour cell preparation (ATCP).
A method for determining whether a tumour cell preparation (TCP) is an activating tumour cell preparation (ATCP), the method comprising the following steps:
- (i) contacting the tumour cell preparation with a NK cell;
- (ii) contacting the NK cell from step (i) with a target cell resistant to lysis by non-activated NK cells;
- (iii) determining whether the target cell is lysed by the NK cell from step (i).
A method for determining whether a tumour cell preparation (TCP) is an activating tumour cell preparation (ATCP), the method having the following steps:
- (i) contacting the tumour cell preparation with a NK cell;
- (ii) determining whether the TCP causes upregulation of CD69 on the NK cell.
Dependencies are inferred from the claim text.