Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use
AssigneeStemCyte, Inc.
InventorRobert Chow
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Abstract
The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
Claims66
An umbilical cord blood (UCB) composition comprising at least about 50% red blood cells by volume and an anticoagulant, wherein plasma is substantially depleted but red blood cells are not depleted.
An umbilical cord blood (UCB) composition comprising at least about 50% red blood cells by volume, a red blood cell concentration of at least about 3.2×106 red blood cells/μl, and an anticoagulant, wherein plasma is substantially depleted but red blood cells are not depleted.
Dependencies are inferred from the claim text.