Activators of Hexosamine Biosynthesis as Inhibitors of Injury Induced by Ischemia or Hermorrhagic Shock
AssigneeThe UAB Research Foundation
InventorsRichard Marchase, Pam Bounelis, John Chatham, Irshad Chaudry, Yi Pang
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Abstract
Disclosed herein are compositions and methods for preserving cell, tissue, or organ transplants and cultures by increasing the concentration of an intracellular metabolite of the hexosamine biosynthetic pathway. Also described herein are methods of reducing pathogenic effects in a subject by increasing the concentration of an intracellular metabolite of the hexosamine biosynthetic pathway.
Claims48
A method of reducing a pathogenic effect caused by stress in a subject, comprising administering to the subject a composition that increases a concentration of an intracellular metabolite of a hexosamine biosynthetic pathway, as compared to the concentration of the intracellular metabolite in the absence of the composition, the increase in the concentration of the intracellular metabolite of the hexosamine biosynthetic pathway reducing the pathogenic effect of the stress in the subject.
A method of preserving a cell, tissue, or organ transplant in a transplant recipient, comprising:
- a. contacting the cell, tissue, or organ transplant with a composition that increases a concentration of an intracellular metabolite of a hexosamine biosynthetic pathway, as compared to the concentration of the intracellular metabolite in the absence of the composition;
- and
- b. transplanting the cell, tissue, or organ into the recipient, the increase in the concentration of the intracellular metabolite of the hexosamine biosynthetic pathway preserving the cell, tissue, or organ transplant in the transplant recipient.
A method of preserving a cell, tissue, or organ culture, comprising contacting the cell, tissue, or organ culture with a composition that increases a concentration of an intracellular metabolite of a hexosamine biosynthetic pathway, as compared to the concentration of the intracellular metabolite in the absence of the composition, the increase in the concentration of the intracellular metabolite of the hexosamine biosynthetic pathway preserving the cell, tissue, or organ culture.
Dependencies are inferred from the claim text.