Receptor-mediated uptake of peptides that bind the human transferrin receptor
OwnerJeffrey A. Engler, Jae Hwy Lee +2inventors
InventorsJeffrey A. Engler, Jae Hwy Lee, James F. Collawn, Bryan A. Moore
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Abstract
Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
Claims25
A method of targeting an agent to a transferrin receptor in a subject, said method comprising the step of administering to the subject a peptide containing the sequence HAIYPRH (SEQ. ID NO:
- 1) linked to the agent.
A method of targeting an agent to a transferrin receptor in a subject, said method comprising the step of administering to the subject a peptide linked to the agent, wherein the peptide binds to the transferrin receptor at a site distinct from a site where transferrin binds the transferrin receptor.
A method of treating a subject in need thereof, the method comprising the step of administering to the subject a peptide linked to an agent, wherein the peptide contains the sequence HAIYPRH (SEQ. ID NO:
- 1) or THRPPMWSPVWP (SEQ ID NO:
- 2) and targets the agent to a cell expressing a transferrin receptor.
Dependencies are inferred from the claim text.