Pegylation and Hydroxylation of Trimetallic Nitride Endohedral Metallofullerenes
AssigneeLuna Innovations Incorporated
InventorsZhongxin Ge, Harry C. Dorn, J. Paige Phillips
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Abstract
A pegylated and hydroxiated trimetallic nitride endohedral metallofullerene is provided comprising a plurality of hydroxyl groups and one or more polyethylene glycol (PEG) moieties covalently bonded to a fullerene encapsulating a trimetallic nitride. Methods of pegylation and hydroxylation of trimetallic nitride endohedral metallofullerene and methods of using pegylated and hydroxlated trimetallic nitride endohedral metallofullerene are described.
Claims20
A pegylated and hydroxlated trimetallic nitride endohedral metallofullerene comprising a plurality of hydroxyl groups and one or more polyethylene glycol moieties covalently bonded to a fullerene encapsulating a trimetallic nitride.
An endohedral metallofullerene of the formula:
- A3-nXnN@Cm(—R(—[—O—CH2CH2—]k-Q)j)i(—OH)h;
- where A and X are metal atoms, n=0-3;
- m is an even number between about 60 and about 200;
- 1<h<m-2;
- i≧1;
- j=1 or 2;
- and k>1.
A method of pegylation and hydroxylation of trimetallic nitride endohedral metallofullerene comprising,
- reacting a malonyl-polyethylene glycol with a trimetallic nitride endohedral metallofullerene to form a pegylated trimetallic nitride endohedral metallofullerene;
- reacting the pegylated trimetallic nitride endohedral metallofullerene with NaOH and TBAH in an organic solvent;
- and, adding H2O and H2O2 to hydroxiate the pegylated trimetallic nitride endohedral metallofullerene.
Dependencies are inferred from the claim text.