Centrifugal fraction collection system and method
AssigneeModular SFC, LLC
InventorHerbert J. Hedberg
Life of this patent
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Abstract
A centrifugal fraction collection system including a rotating carrier for holding at least one sample collection container and inducing a centrifugal force, a guide disposed on the rotating carrier, and a flexible eluant tube disposed over the rotating carrier and through the guide for receiving a flow of eluant having volatile and non-volatile components and directing the flow of eluant into at least one sample collection container wherein the centrifugal force separates the non-volatile and volatile components based on their respective densities and collects the non-volatile components in at least one sample collection container.
Claims25
A centrifugal fraction collection system comprising:
- a rotating carrier for holding at least one sample collection container and inducing a centrifugal force;
- a guide disposed on the rotating carrier;
- and
- a flexible eluant tube disposed over the rotating carrier and through the guide for receiving a flow of eluant having volatile and non-volatile components and directing the flow of eluant into at least one sample collection container wherein the centrifugal force separates the non-volatile and volatile components based on their respective densities and collects the non-volatile components in at least one sample collection container.
The system of claim of 1 in which the flexible eluant tube extends a predetermined length into a sample collection for increasing the yield of the non-volatile components.
A centrifugal fraction collection system comprising:
- a rotating carrier for holding at least one sample collection container and inducing a centrifugal force;
- and
- an eluant tube disposed over the rotating carrier and coupled to the rotating carrier for receiving a flow of eluant having volatile and non-volatile components and directing the flow of eluant into at least one sample collection container wherein the centrifugal force separates the non-volatile and volatile components based on their respective densities and collects the non-volatile components in at least one sample collection container.
A method for centrifugal fraction collection comprising:
- providing a flow of eluant having non-volatile components and volatile components;
- providing a rotating carrier for holding one or more sample collection containers;
- providing a flexible eluant tube receiving the flow of eluant;
- inducing a centrifugal force on a rotating carrier;
- and
- wherein the centrifugal force separates the non-volatile components from the volatile components based on their respective densities and collects the non-volatile components in the one or more sample collection containers
A flash super critical chromatography system and collection subsystem comprising:
- a source of supercritical fluid solvent;
- a source of organic modifier solvent;
- a source of eluant having non-volatile components and volatile components therein;
- a selector valve coupled to the source of supercritical solvent and the source of organic modifier configured to provide a pressurized flow of the eluant;
- a mixer coupled to the selector valve for receiving the pressurized flow of eluant and for mixing periodic boluses of alternating supercritical solvent and organic modifier;
- an injector subsystem for injecting a sample into the pressurized flow of eluant;
- a chromatography column coupled to the injector for receiving the pressurized flow of eluant;
- a phase transition tube for reducing the pressure of the flow of eluant;
- and
- a fraction collection subsystem including:
- a rotating carrier for holding at least one sample collection container and inducing a centrifugal force,
- a flexible eluant tube disposed above the rotating carrier and coupled to the rotating carrier and/or through a guide on the rotating carrier for receiving the flow of eluant at the reduced pressure, and
- wherein the centrifugal force separates the volatile and non-volatile components of the eluant based on their respective densities and collects the non-volatile components in the at least one sample collection container.
Dependencies are inferred from the claim text.