Oligonucleotide-Containing Pharmacological Compositions And Their Use
AssigneeLakewood Amedex, Inc.
InventorsRoderic M.K. Dale, Amy Arrow, Terry Thompson
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Abstract
The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
Claims53
A composition suitable for administration in a mammal comprising a modified oligonucleotide of about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphate linkages, wherein the modified oligonucleotide is complementary to a region of a gene associated with a pathological disorder.
A method of treating a patient with a pathological disorder comprising administering one or more modified oligonucleotides of about seven to seventy-five nucleotides, wherein the modified oligonucleotide contains seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphate linkages.
A nutritional supplement comprising a modified oligonucleotide of about seven to seventy-file nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphate linkages.
A cosmetic composition comprising a modified oligonucleotide of about seven to seventy-file nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphate linkages, wherein the modified oligonucleotide is complementary to a region of a gene associated with a skin disorder.
Dependencies are inferred from the claim text.