A method of determining whether a liquid amount and/or quality of a liquid reagent held in a reagent holding portion are/is normal in a liquid-reagent-containing microchip including, at least, two or more reagent holding portions for holding two or more types of liquid reagents respectively, two or more first measuring portions for measuring said two or more types of liquid reagents respectively, and a first mixing portion for mixing the two or more types of liquid reagents measured with said first measuring portions, comprising the steps of:
- (A) measuring each liquid reagent held in said reagent holding portion with said first measuring portions;
- (B) mixing, at least, two or more types of measured liquid reagents in said first mixing portion;
- and
- (C) evaluating a liquid amount and/or quality of a liquid mixture obtained in said step (B) and determining whether the liquid amount and/or quality of the liquid reagents held in said reagent holding portions are/is normal, based on the evaluation.