Substituted Hydroxyethylamines

A compound of the formula I

• wherein
• W is selected from the group consisting of (i) C6-C10 aryl optionally substituted with one to three substituents each independently selected from H, halogen, CN, NO2, OH, O—C1-C8 alkyl, NH2, NH—C1-C8alkyl, N(C1-C8alkyl)2, NHCO—C1-C8alkyl, and CONH—C1-C8alkyl, and (ii) C5-C10 heteroaryl optionally substituted with one to three substituents each independently selected from H, halogen, CN, NO2, OH, O—C1-C8 alkyl, NH2, NH—C1-C8 alkyl, N(C1-C8 alkyl)2, NHCO—C1-C8 alkyl, and CONH—C1-C8 alkyl,
• R1 is C1-C6 alkyl, optionally substituted with up to three fluoro atoms;
• R5 and R6 are each independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C3-C8 alkynyl, C3-C5 cycloalkyl, 5-10 membered heteroaryl, and C6-C14 aryl;
• p is from 0 to 1,
• represents a single or double bond, with the proviso that if is a double bond, X is N, C(C1-C6 alkyl), or O, with the proviso that if X is O and p is 1, R10 is absent;
• and with the proviso that if is a single bond, X is C0-C6 alkylene, C(═C1-C6 alkylidene), C(—N—O—C1-C6 alkyl), C(═N—C1-C6 alkyl), C═O, NH, NC1-C6 alkyl, or O;
• and
• R10 is selected from the group consisting of H, C1-C6 alkyl, —OH, —O—C1-C6 alkyl, —CO—C1-C6 alkyl, —COO—C1-C6 alkyl, —NH—C1-C6 alkyl, —N(C1-C6 alkyl)-C1-C6 alkyl, —CO—N(C1-C6 alkyl)-C1-C6 alkyl, 5-10 membered heteroaryl, 5-10-membered heterocycloalkyl, C6-C14 aryl, S(O)qC1-C6 alkyl, and S(O)qC6-C10 aryl.