Injection of therapeutic into porous regions of a medical device

A method of injecting therapeutic into pores of a medical device, the method comprising:

• providing a medical device sized to be inserted into a patient, the medical device having at least a portion thereof comprising a porous region, the porous region having a plurality of pores sized with a mean pore size of 10−3 meters or smaller;
• providing an injector containing a therapeutic and having an exit orifice;
• positioning the exit nozzle to be in fluid communication with the medical device;
• and
• ejecting therapeutic from the exit orifice of the injector and into a plurality of the pores in the porous region of the medical device,
• wherein the therapeutic is ejected at pressures greater than about 100 bar.