Benzoureas Having Anti-Diabetic Activity

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is —X-Aryl-Y-Z, wherein Aryl is optionally substituted with 1-3 groups independently selected from A;
• Aryl is phenyl or naphthyl;
• X and Y are each independently selected from the group consisting of a bond and —CR4R5—;
• Z is
• Q is selected from the group consisting of S and O;
• A is selected from the group consisting of C1-C4 alkyl, C2-C4 alkenyl, —OC1-C4 alkyl, and halogen, wherein alkyl, alkenyl, and —Oalkyl are each optionally substituted with 1-5 halogens;
• R2 is selected from the group consisting of
• (a) Benzisoxazolyl,
• (b) Aryl,
• (c) —(CH2)Aryl,
• (d) —(C═O)Aryl, and
• (e) benzothiazolyl, wherein
• R2 is optionally substituted with 1-3 substituent groups independently selected from halogen, C1-C3 alkyl, and —OC1-C3 alkyl, wherein C1-C3 alkyl and —OC1-C3 alkyl are optionally substituted with 1-5 halogens;
• R3 is selected from the group consisting of halogen, C1-C3 alkyl, and —OC1-C3 alkyl, wherein C1-C3 alkyl and —OC1-C3 alkyl are optionally substituted with 1-5 halogens;
• R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, and —OC1-C3 alkyl, wherein C1-C3 alkyl and —OC1-C3 alkyl are optionally substituted with 1-5 halogens;
• R6 is selected from the group consisting of H, C1-C3 alkyl, and halogen, wherein C1-C3 alkyl is optionally substituted with 1-3F;
• and
• p is an integer from 0 to 4.