Benzene, Pyridine, and Pyridazine Derivatives

A compound of the formula

• or a pharmaceutically acceptable salt thereof, wherein
• p is 0, 1, 2, 3, 4, or 5;
• m is 0, 1, 2, 3, 4, or 5, provided that the sum of m and p is less than or equal to 5;
• each q is independently 0, 1, or 2;
• each R is independently halogen, cyano, nitro, C1-C6 alkyl, halo(C1-C6)alkyl, hydroxy, C1-C6 alkoxy, halo(C1-C6)alkoxy, amino, mono- or di-(C1-C6) alkylamino, carboxy, carboxamide, C3-C7 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• each RC is independently halogen, cyano, nitro, —ORO, —N(RN)2, SRO, or —RN;
• each RN is independently —RN′, —C(O)RN′, —C(O)ORN′, —C(O)N(RN′)2, —S(O)RN′, or —S(O)2RN′ wherein
• each RN′ is independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl (C1-C10)alkyl, heterocycloalkyl, heterocycloalkyl (C1-C10)alkyl, aryl, aryl (C1-C10)alkyl, heteroaryl, or heteroaryl(C1-C10)alkyl, wherein
• each RN′ is optionally substituted with from 1 to 4 R groups;
• each RO is independently —RN′, —C(O)RN′, —C(O)ORN′, or —C(O)N(RN′)2;
• R3 and R4 are independently (a) hydrogen, (b) halo, or (c) a C1-C15 alkyl group where up to six of the carbon atoms in said alkyl group are optionally replaced independently by R22, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, or S(O)q, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent each other, wherein
• each R22 is independently (i) heteroaryl, (ii) aryl, (iii) saturated or unsaturated C3-C10 cycloalkyl, or (iv) saturated or unsaturated C2-C10 heterocycloalkyl, wherein
• each R22 is optionally substituted with 1 to 4 groups which are independently —R, oxo, —SH, —S(O)q—(C1-C6)alkyl, —S(O)q-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, or —SO2NH-aryl;
• and
• each R22 is optionally fused to a C6-C10 aryl group, C5-C8 saturated cyclic group, or a C5-C10 heterocycloalkyl group;
• and
• each (c) is optionally substituted with —RC, —OR15, —SR15, or —N(R15)2, or —R22, wherein
• each R15 is independently —H, (C1-C10)alkyl, (C1-C10) haloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C1-C10)alkyl-Z, wherein
• Z is —OR0 or —N(R30)2, wherein
• each R30 is independently —H or C1-C6 alkyl;
• or N(R30)2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl, or morpholinyl, each of which is optionally substituted with R;
• and
• or R3 and R4 together with the atoms to which they are attached form a 5-12 membered mono-, bi-, or tricyclic ring system fused to the ring containing Q1 and Q2, where the 5-12 membered ring is partially unsaturated or aromatic and optionally contains one or two of oxygen, S(O)q, nitrogen, or NR33 where R33 is hydrogen or C1-C6 alkyl;
• Q1, Q2, and Q3 are independently N or CRQ, with the proviso that at least one Q1, Q2, or Q3 is CRQ, wherein
• each RQ is independently hydrogen, halogen, —N(RN)2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, aryl, or heteroaryl, or —R21, wherein each RQ is optionally substituted with from 1-4 R groups, wherein
• R21 is cyano, —C(O)OH, —C(O)—O(C1-C6alkyl), —C(X)N(R1)2, wherein
• each R1 is independently hydrogen, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, heteroaryl, aryl, C3-C8 cycloalkyl, heterocycloalkyl,
• wherein each R1 is optionally substituted with from 1-4 R groups;
• or both R1 together with the nitrogen to which they are attached, form a heterocycloalkyl;
• and
• X is ═O, ═S, ═NH, ═NOH, ═N—NH2, ═N—NH-aryl, ═N-=NH— (C1-C6 alkyl), or ═N—(C1-C6 alkoxy);
• A is a bond, O, S(O)q, N(RN), C(O), or CH(RC);
• and each R5 is independently RC.