Method of Treating Latent Tuberculosis
AssigneeEvanston Northwestern Healthcare
InventorsMaria Papadopoulou, William Bloomer
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Abstract
2-Nitroimidazolyl-alkylaminoquinolines, and compositions containing the same, useful in the treatment of tuberculosis are disclosed. Methods of treating tuberculosis using the 2-nitroimidazolyl-alkylaminoquinolines, and compositions containing the same, also are disclosed.
Claims12
A method of treating tuberculosis comprising administering a therapeutically-effective amount of a 2-nitroimidazolyl-alkylaminoquinoline, or a pharmaceutically acceptable salt thereof, to an individual in need thereof, wherein the 2-nitroimidazolyl-alkylaminoquinoline has a structural formula
- wherein R1 is present at the 6, 7, or 8 position of the quinoline ring and is selected from the group consisting of halo, methyl, methoxy, and trifluoromethyl, and n is an integer 2 through 6.
An article of manufacture comprising:
- (a) a packaged composition comprising a 2-nitroimidazolyl-alkylaminoquinoline having a structural formula
- wherein R1 is present at the 6, 7, or 8 position of the quinoline ring and is selected from the group consisting of halo, methyl, methoxy, and trifluoromethyl, and n is an integer 2 through 6;
- (b) an insert providing instructions for administration of the packaged composition of (a) to treat tuberculosis;
- and
- (c) a container for (a) and (b).
An article of manufacture comprising:
- (a) a packaged composition comprising a 2-nitroimidazolyl-alkylaminoquinoline having a structural formula
- wherein R1 is present at the 6, 7, or 8 position of the quinoline ring and is selected from the group consisting of halo, methyl, methoxy, and trifluoromethyl, and n is an integer 2 through 6;
- (b) a packaged composition comprising a second therapeutic agent useful in a treatment of tuberculosis;
- (c) an insert providing instructions for a simultaneous or sequential administration of (a) and (b) to treat tuberculosis;
- and
- (d) a container for (a), (b), and (c).
Dependencies are inferred from the claim text.