Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors

Compound of the general formula

• in which,
• X is C;
• Y is C or N;
• Z is C;
• R
• a) is hydrogen;
• or
• b) is C1-C8-alkyl, C1-C8-alkoxy, halogen or trifluoromethyl;
• R1 is aryl-C0-C4-alkyl or unsaturated heterocyclyl-C0-C4-alkyl, which radicals are unsubstituted or substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulfonyl, aryl-C0-C4-alkoxycarbonyl, aryl, cyano, halogen, heterocyclyl, oxo, trifluoromethoxy, trifluoromethyl or tri-C1-C4-alkylsilyl;
• R2
• a) is hydrogen;
• or
• b) is C1-C8-alkyl, C3-C8-cycloalkyl, halogen, carboxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C0-C4-alkylcarbonyl, aryl-C0-C4-alkyl or unsaturated heterocyclyl-C1-C4-alkyl, which radicals are unsubstituted or substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulfonyl, aryl-C0-C4-alkoxycarbonyl, aryl, cyano, halogen, heterocyclyl, oxo, trifluoromethoxy, trifluoromethyl or tri-C1-C4-alkylsilyl;
• n is a number 0, 1 or 2;
• whereby the term heterocyclyl stands for a saturated, partially saturated or unsaturated, 4-8-membered monocyclic ring system, for a saturated, partially saturated or unsaturated, 7-12-membered bicyclic ring system and also for a saturated, partially saturated or unsaturated, 7-12-membered tricyclic ring system, in each case comprising an N, O or S atom in at least one ring;
• * designates an asymmetric carbon atom
• and its salt, prodrug or compound in which one or more atoms are replaced by their stable, nonradioactive isotopes, in particular pharmaceutically usable salt,
• where, if X, Y and Z are C, R1 is not an unsubstituted or alkoxy-substituted benzyl radical;
• and excluding the compounds 5,6,7,8-tetrahydro-8-(4-pyridinyl)-isoquinoline and 5,6,7,8-tetrahydro-8-(4-pyridinyl)-isoquinoline.