Novel Lactams And Uses Thereof
AssigneeAstraZeneca AB
InventorsChristopher Becker, Bruce Dembofsky, Robert Jacobs, James Kang, Cyrus Ohnmacht, James Rosamond, Ashokkumar Shenvi, Thomas Simpson, James Woods
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Abstract
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
Claims4
1-30. (canceled)
A pharmaceutical composition comprising a compound that functions to inhibit γ secretase comprising a substituted structure of 6-amino-7-phenyl-1,4-thiazepan-5-one.
A pharmaceutical composition comprising a compound that functions to inhibit γ secretase comprising a substituted structure of 3-amino-2-(2,5-difluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one.
A pharmaceutical composition comprising a compound that functions to inhibit γ secretase comprising a substituted structure of 3-amino-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one.
Dependencies are inferred from the claim text.